Nuclear IRF-1 expression as a mechanism to assess “Capability” to express PD-L1 and response to PD-1 therapy in metastatic melanoma

BACKGROUND: Predictive biomarkers for antibodies against programmed death 1 (PD-1) remain a major unmet need in metastatic melanoma. Specifically, response is seen in tumors that do not express programmed death ligand 1 (PD-L1), highlighting the need for a more sensitive biomarker. We hypothesize th...

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Publicado en:J Immunother Cancer
Autores principales: Smithy, James W., Moore, Lauren M., Pelekanou, Vasiliki, Rehman, Jamaal, Gaule, Patricia, Wong, Pok Fai, Neumeister, Veronique M., Sznol, Mario, Kluger, Harriet M., Rimm, David L.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359951/
https://ncbi.nlm.nih.gov/pubmed/28331615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-017-0229-2
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