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The spatiotemporal pattern and intensity of p53 activation during embryogenesis dictates phenotypic diversity in p53-driven developmental syndromes
Inappropriate activation of the p53 transcription factor contributes to numerous developmental syndromes characterized by distinct constellations of phenotypes. How p53 drives exquisitely specific sets of symptoms in diverse syndromes, however, remains enigmatic. Here, we deconvolute the basis of p5...
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| Publicado en: | Dev Cell |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6650355/ https://ncbi.nlm.nih.gov/pubmed/31178404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.05.015 |
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