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Guilty as CHARGED: p53's expanding role in disease
Unrestrained p53 activity during development, as occurs upon loss of the p53 negative regulators Mdm2 or Mdmx, causes early embryonic lethality. Surprisingly, co-expression of wild-type p53 and a transcriptionally-dead variant of p53, with mutations in both transactivation domains (p53(L25Q,W26S,F53...
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| Publicado no: | Cell Cycle |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4613992/ https://ncbi.nlm.nih.gov/pubmed/25483057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.987627 |
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