Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity

Histone deacetylases (HDACs) have been identified as promising epigenetic drug targets for the treatment of neuroblastoma and glioblastoma. In this work, we have rationally designed a novel class of peptoid-based histone deacetylase inhibitors (HDACi). A mini library of β-peptoid-capped HDACi was sy...

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Vydáno v:Medchemcomm
Hlavní autoři: Reßing, Nina, Marquardt, Viktoria, Gertzen, Christoph G. W., Schöler, Andrea, Schramm, Alexander, Kurz, Thomas, Gohlke, Holger, Aigner, Achim, Remke, Marc, Hansen, Finn K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2018
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6644563/
https://ncbi.nlm.nih.gov/pubmed/31391882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00454d
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