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Targeting dynamic ATP-binding site features allows discrimination between highly homologous protein kinases
ATP-competitive inhibitors that demonstrate exquisite selectivity for specific members of the human kinome have been developed. Despite this success, the identification of highly selective inhibitors is still very challenging, and it is often not possible to rationally engineer selectivity between t...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6642640/ https://ncbi.nlm.nih.gov/pubmed/31038916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00214 |
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