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Importance of lipophilicity for potent anti-herpes simplex virus-1 activity of α-hydroxytropolones
We previously reported that troponoid compounds profoundly inhibit replication of herpes simplex virus (HSV)-1 and HSV-2 in cell culture, including acyclovir-resistant mutants. Synthesis of 26 alpha-hydroxylated tropolones (αHTs) led to a preliminary structure–activity relationship highlighting the...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6640544/ https://ncbi.nlm.nih.gov/pubmed/31391890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00225a |
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