Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

Here we describe a rapid and divergent synthetic route toward structurally novel αHTs functionalized with either one or two thioether or sulfonyl appendages. Evaluation of this library against hepatitis B and herpes simplex virus, as well as the pathogenic fungus Cryptococcus neoformans, revealed co...

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Bibliografische gegevens
Gepubliceerd in:RSC Adv
Hoofdauteurs: Agyemang, Nana B., Kukla, Cassandra R., Edwards, Tiffany C., Li, Qilan, Langen, Madison K., Schaal, Alexandra, Franson, Abaigeal D., Casals, Andreu Gazquez, Donald, Katherine A., Yu, Alice J., Donlin, Maureen J., Morrison, Lynda A., Tavis, John E., Murelli, Ryan P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Royal Society of Chemistry 2019
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543996/
https://ncbi.nlm.nih.gov/pubmed/33042521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ra06383h
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