Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

Here we describe a rapid and divergent synthetic route toward structurally novel αHTs functionalized with either one or two thioether or sulfonyl appendages. Evaluation of this library against hepatitis B and herpes simplex virus, as well as the pathogenic fungus Cryptococcus neoformans, revealed co...

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Bibliografiske detaljer
Udgivet i:RSC Adv
Main Authors: Agyemang, Nana B., Kukla, Cassandra R., Edwards, Tiffany C., Li, Qilan, Langen, Madison K., Schaal, Alexandra, Franson, Abaigeal D., Casals, Andreu Gazquez, Donald, Katherine A., Yu, Alice J., Donlin, Maureen J., Morrison, Lynda A., Tavis, John E., Murelli, Ryan P.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society of Chemistry 2019
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543996/
https://ncbi.nlm.nih.gov/pubmed/33042521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ra06383h
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