Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

Here we describe a rapid and divergent synthetic route toward structurally novel αHTs functionalized with either one or two thioether or sulfonyl appendages. Evaluation of this library against hepatitis B and herpes simplex virus, as well as the pathogenic fungus Cryptococcus neoformans, revealed co...

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Dettagli Bibliografici
Pubblicato in:RSC Adv
Autori principali: Agyemang, Nana B., Kukla, Cassandra R., Edwards, Tiffany C., Li, Qilan, Langen, Madison K., Schaal, Alexandra, Franson, Abaigeal D., Casals, Andreu Gazquez, Donald, Katherine A., Yu, Alice J., Donlin, Maureen J., Morrison, Lynda A., Tavis, John E., Murelli, Ryan P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society of Chemistry 2019
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543996/
https://ncbi.nlm.nih.gov/pubmed/33042521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ra06383h
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