Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

Here we describe a rapid and divergent synthetic route toward structurally novel αHTs functionalized with either one or two thioether or sulfonyl appendages. Evaluation of this library against hepatitis B and herpes simplex virus, as well as the pathogenic fungus Cryptococcus neoformans, revealed co...

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Detalhes bibliográficos
Publicado no:RSC Adv
Main Authors: Agyemang, Nana B., Kukla, Cassandra R., Edwards, Tiffany C., Li, Qilan, Langen, Madison K., Schaal, Alexandra, Franson, Abaigeal D., Casals, Andreu Gazquez, Donald, Katherine A., Yu, Alice J., Donlin, Maureen J., Morrison, Lynda A., Tavis, John E., Murelli, Ryan P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543996/
https://ncbi.nlm.nih.gov/pubmed/33042521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ra06383h
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