Efficacy and Cytotoxicity in Cell Culture of Novel α-Hydroxytropolone Inhibitors of Hepatitis B Virus Ribonuclease H

Chronic Hepatitis B virus (HBV) infection is a major worldwide public health problem. Current direct-acting anti-HBV drugs target the HBV DNA polymerase activity, but the equally essential viral ribonuclease H (RNaseH) activity is unexploited as a drug target. Previously, we reported that α–hydroxyt...

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Foilsithe in:Antiviral Res
Main Authors: Lomonosova, Elena, Daw, Jil, Garimallaprabhakaran, Aswin K., Agyemang, Nana B., Ashani, Yashkumar, Murelli, Ryan P., Tavis, John E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549669/
https://ncbi.nlm.nih.gov/pubmed/28633989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2017.06.014
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