Importance of lipophilicity for potent anti-herpes simplex virus-1 activity of α-hydroxytropolones

We previously reported that troponoid compounds profoundly inhibit replication of herpes simplex virus (HSV)-1 and HSV-2 in cell culture, including acyclovir-resistant mutants. Synthesis of 26 alpha-hydroxylated tropolones (αHTs) led to a preliminary structure–activity relationship highlighting the...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Berkowitz, Alex J., Franson, Abaigeal D., Gazquez Cassals, Andreu, Donald, Katherine A., Yu, Alice J., Garimallaprabhakaran, Aswin K., Morrison, Lynda A., Murelli, Ryan P.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2019
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640544/
https://ncbi.nlm.nih.gov/pubmed/31391890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00225a
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