Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

CCR4-NOT is a conserved multiprotein complex which regulates eukaryotic gene expression principally via shortening of poly(A) tails of messenger RNA or deadenylation. Here, we reconstitute a complete, recombinant human CCR4-NOT complex. Our reconstitution strategy permits strict compositional contro...

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Publicado en:Nat Commun
Autores principales: Raisch, Tobias, Chang, Chung-Te, Levdansky, Yevgen, Muthukumar, Sowndarya, Raunser, Stefan, Valkov, Eugene
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639331/
https://ncbi.nlm.nih.gov/pubmed/31320642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11094-z
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