A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay

XRN1 is the major cytoplasmic exoribonuclease in eukaryotes, which degrades deadenylated and decapped mRNAs in the last step of the 5′–3′ mRNA decay pathway. Metazoan XRN1 interacts with decapping factors coupling the final stages of decay. Here, we reveal a direct interaction between XRN1 and the C...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Chang, Chung-Te, Muthukumar, Sowndarya, Weber, Ramona, Levdansky, Yevgen, Chen, Ying, Bhandari, Dipankar, Igreja, Catia, Wohlbold, Lara, Valkov, Eugene, Izaurralde, Elisa
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753473/
https://ncbi.nlm.nih.gov/pubmed/31340047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz633
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