A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay

XRN1 is the major cytoplasmic exoribonuclease in eukaryotes, which degrades deadenylated and decapped mRNAs in the last step of the 5′–3′ mRNA decay pathway. Metazoan XRN1 interacts with decapping factors coupling the final stages of decay. Here, we reveal a direct interaction between XRN1 and the C...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Chang, Chung-Te, Muthukumar, Sowndarya, Weber, Ramona, Levdansky, Yevgen, Chen, Ying, Bhandari, Dipankar, Igreja, Catia, Wohlbold, Lara, Valkov, Eugene, Izaurralde, Elisa
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
RNA and RNA-protein complexes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753473/
https://ncbi.nlm.nih.gov/pubmed/31340047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz633
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