CD4(+) T Cells Drive Lung Disease Enhancement Induced by Immunization with Suboptimal Doses of Respiratory Syncytial Virus Fusion Protein in the Mouse Model

Respiratory syncytial virus (RSV) infection of seronegative children previously immunized with formalin-inactivated (FI) RSV has been associated with serious enhanced respiratory disease (ERD). The phenomenon was reproduced in the cotton rat and the mouse, and both preclinical models have been routi...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Schneider-Ohrum, Kirsten, Snell Bennett, Angie, Rajani, Gaurav Manohar, Hostetler, Leigh, Maynard, Sean K., Lazzaro, Michelle, Cheng, Lily I., O’Day, Terrence, Cayatte, Corinne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639276/
https://ncbi.nlm.nih.gov/pubmed/31092578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00695-19
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