Immunization with Low Doses of Recombinant Postfusion or Prefusion Respiratory Syncytial Virus F Primes for Vaccine-Enhanced Disease in the Cotton Rat Model Independently of the Presence of a Th1-Biasing (GLA-SE) or Th2-Biasing (Alum) Adjuvant

Respiratory syncytial virus (RSV) infection of children previously immunized with a nonlive, formalin-inactivated (FI)-RSV vaccine has been associated with serious enhanced respiratory disease (ERD). Consequently, detailed studies of potential ERD are a critical step in the development of nonlive RS...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Schneider-Ohrum, Kirsten, Cayatte, Corinne, Bennett, Angie Snell, Rajani, Gaurav Manohar, McTamney, Patrick, Nacel, Krystal, Hostetler, Leigh, Cheng, Lily, Ren, Kuishu, O'Day, Terrence, Prince, Gregory A., McCarthy, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375676/
https://ncbi.nlm.nih.gov/pubmed/28148790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02180-16
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