Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice.

Respiratory syncytial virus (RSV) is recognized as an important cause of lower and upper respiratory tract infections in older adults, and a successful vaccine would substantially lower morbidity and mortality in this age group. Recently, two vaccine candidates based on soluble purified glycoprotein...

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Main Authors: Corinne Cayatte, Angie Snell Bennett, Gaurav Manohar Rajani, Leigh Hostetler, Sean K Maynard, Michelle Lazzaro, Patrick McTamney, Kuishu Ren, Terrence O'Day, Michael P McCarthy, Kirsten Schneider-Ohrum
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2017-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC5705161?pdf=render
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