Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells

Dopamine and cAMP-regulated phosphoprotein, Mr 32000 (DARPP-32), is frequently overexpressed in earlt stages of gastric cancers. We utilized in vitro assays, 3D gastric gland organoid cultures, mouse models, and human tissue samples to investigate the biological and molecular impact of DARPP-32 on a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncogene
Prif Awduron: Zhu, Shoumin, Soutto, Mohammed, Chen, Zheng, Piazuelo, M. Blanca, Washington, M. Kay, Belkhiri, Abbes, Zaika, Alexander, Peng, Dunfa, El-Rifai, Wael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639157/
https://ncbi.nlm.nih.gov/pubmed/31235784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0843-1
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