Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells

Dopamine and cAMP-regulated phosphoprotein, Mr 32000 (DARPP-32), is frequently overexpressed in earlt stages of gastric cancers. We utilized in vitro assays, 3D gastric gland organoid cultures, mouse models, and human tissue samples to investigate the biological and molecular impact of DARPP-32 on a...

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Foilsithe in:Oncogene
Main Authors: Zhu, Shoumin, Soutto, Mohammed, Chen, Zheng, Piazuelo, M. Blanca, Washington, M. Kay, Belkhiri, Abbes, Zaika, Alexander, Peng, Dunfa, El-Rifai, Wael
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639157/
https://ncbi.nlm.nih.gov/pubmed/31235784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0843-1
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