Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells

Dopamine and cAMP-regulated phosphoprotein, Mr 32000 (DARPP-32), is frequently overexpressed in earlt stages of gastric cancers. We utilized in vitro assays, 3D gastric gland organoid cultures, mouse models, and human tissue samples to investigate the biological and molecular impact of DARPP-32 on a...

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Pubblicato in:Oncogene
Autori principali: Zhu, Shoumin, Soutto, Mohammed, Chen, Zheng, Piazuelo, M. Blanca, Washington, M. Kay, Belkhiri, Abbes, Zaika, Alexander, Peng, Dunfa, El-Rifai, Wael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639157/
https://ncbi.nlm.nih.gov/pubmed/31235784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0843-1
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