Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells

Dopamine and cAMP-regulated phosphoprotein, Mr 32000 (DARPP-32), is frequently overexpressed in earlt stages of gastric cancers. We utilized in vitro assays, 3D gastric gland organoid cultures, mouse models, and human tissue samples to investigate the biological and molecular impact of DARPP-32 on a...

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Bibliografiska uppgifter
I publikationen:Oncogene
Huvudupphovsmän: Zhu, Shoumin, Soutto, Mohammed, Chen, Zheng, Piazuelo, M. Blanca, Washington, M. Kay, Belkhiri, Abbes, Zaika, Alexander, Peng, Dunfa, El-Rifai, Wael
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639157/
https://ncbi.nlm.nih.gov/pubmed/31235784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0843-1
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