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Androgen Deprivation Leads to Increased Carbohydrate Metabolism and Hexokinase 2 Mediated Survival in Pten/Tp53 Deficient Prostate Cancer

Prostate cancer is characterized by a dependence upon androgen receptor (AR) signaling, and androgen deprivation therapy (ADT) is the accepted treatment for progressive prostate cancer. Although ADT is usually initially effective, acquired resistance, termed castrate resistant prostate cancer (CRPC)...

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Dettagli Bibliografici
Pubblicato in:Oncogene
Autori principali: Martin, Philip L., Yin, Juan-Juan, Seng, Victoria, Casey, Orla, Corey, Eva, Morrissey, Colm, Simpson, R. Mark, Kelly, Kathleen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639059/
https://ncbi.nlm.nih.gov/pubmed/27375016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.223
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