Self-Renewing Pten(-/-)TP53(-/-) Protospheres Produce Metastatic Adenocarcinoma Cell Lines with Multipotent Progenitor Activity

Prostate cancers of luminal adenocarcinoma histology display a range of clinical behaviors. Although most prostate cancers are slow-growing and indolent, a proportion is aggressive, developing metastasis and resistance to androgen deprivation treatment. One hypothesis is that a portion of aggressive...

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Bibliographische Detailangaben
Hauptverfasser: Abou-Kheir, Wassim, Hynes, Paul G., Martin, Philip, Yin, Juan Juan, Liu, Yen-Nien, Seng, Victoria, Lake, Ross, Spurrier, Joshua, Kelly, Kathleen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191168/
https://ncbi.nlm.nih.gov/pubmed/22022528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026112
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