Androgen Deprivation Leads to Increased Carbohydrate Metabolism and Hexokinase 2 Mediated Survival in Pten/Tp53 Deficient Prostate Cancer

Prostate cancer is characterized by a dependence upon androgen receptor (AR) signaling, and androgen deprivation therapy (ADT) is the accepted treatment for progressive prostate cancer. Although ADT is usually initially effective, acquired resistance, termed castrate resistant prostate cancer (CRPC)...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Martin, Philip L., Yin, Juan-Juan, Seng, Victoria, Casey, Orla, Corey, Eva, Morrissey, Colm, Simpson, R. Mark, Kelly, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639059/
https://ncbi.nlm.nih.gov/pubmed/27375016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.223
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