HiChIRP reveals RNA-associated chromosome conformation

Modular domains of long non-coding RNAs can serve as scaffolds to bring distant regions of the linear genome into spatial proximity. Here, we present HiChIRP, a method leveraging bio-orthogonal chemistry and optimized chromosome conformation capture conditions, which enables interrogation of chromat...

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Pubblicato in:Nat Methods
Autori principali: Mumbach, Maxwell R., Granja, Jeffrey M., Flynn, Ryan A., Roake, Caitlin M., Satpathy, Ansuman T., Rubin, Adam J., Qi, Yanyan, Jiang, Zhaozhao, Shams, Shadi, Louie, Bryan H., Guo, Jimmy K., Gennert, David G., Corces, M. Ryan, Khavari, Paul A., Atianand, Maninjay K., Artandi, Steven E., Fitzgerald, Katherine A., Greenleaf, William J., Chang, Howard Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6638558/
https://ncbi.nlm.nih.gov/pubmed/31133759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0407-x
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