Radiosynthesis and in Vivo Evaluation of [(11)C]MPC-6827(,) the First Brain Penetrant Microtubule PET Ligand

Abnormalities of microtubules (MTs) are implicated in the pathogenesis of many CNS diseases. Despite the potential of an MT imaging agents, no PET ligand is currently available for in vivo imaging of MTs in the brain. We radiolabeled [(11)C]MPC-6827, a high affinity MTA, and demonstrated its specifi...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Kumar, J. S. Dileep, Sai, Kiran Kumar Solingapuram, Prabhakaran, Jaya, Oufkir, Hakeem R., Ramanathan, Gayathri, Whitlow, Christopher T., Dileep, Hima, Mintz, Akiva, Mann, J. John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637745/
https://ncbi.nlm.nih.gov/pubmed/29457976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00028
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