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Radiosynthesis and in Vivo Evaluation of [(11)C]MPC-6827(,) the First Brain Penetrant Microtubule PET Ligand
Abnormalities of microtubules (MTs) are implicated in the pathogenesis of many CNS diseases. Despite the potential of an MT imaging agents, no PET ligand is currently available for in vivo imaging of MTs in the brain. We radiolabeled [(11)C]MPC-6827, a high affinity MTA, and demonstrated its specifi...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6637745/ https://ncbi.nlm.nih.gov/pubmed/29457976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00028 |
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