Radiosynthesis and in Vivo Evaluation of [(11)C]MPC-6827(,) the First Brain Penetrant Microtubule PET Ligand

Abnormalities of microtubules (MTs) are implicated in the pathogenesis of many CNS diseases. Despite the potential of an MT imaging agents, no PET ligand is currently available for in vivo imaging of MTs in the brain. We radiolabeled [(11)C]MPC-6827, a high affinity MTA, and demonstrated its specifi...

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Udgivet i:J Med Chem
Main Authors: Kumar, J. S. Dileep, Sai, Kiran Kumar Solingapuram, Prabhakaran, Jaya, Oufkir, Hakeem R., Ramanathan, Gayathri, Whitlow, Christopher T., Dileep, Hima, Mintz, Akiva, Mann, J. John
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637745/
https://ncbi.nlm.nih.gov/pubmed/29457976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00028
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