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Radiosynthesis and evaluation of [(11)C]CMP, a high affinity GSK3 ligand

Dysfunction of GSK3 is implicated in the etiology of many brain, inflammatory, cardiac diseases, and cancer. PET imaging would enable in vivo detection and quantification of GSK3 and can impact the choice of therapy, allow non-invasive monitoring of disease progression and treatment effects. In this...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Prabhakaran, Jaya, Solingapuram Sai, Kiran Kumar, Sattiraju, Anirudh, Mintz, Akiva, Mann, J. John, Kumar, J.S. Dileep
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703381/
https://ncbi.nlm.nih.gov/pubmed/30709652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.01.033
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