Radiosynthesis and in Vivo Evaluation of [(11)C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain

Dysfunction of glycogen synthase kinase 3 (GSK-3) is implicated in the etiology of Alzheimer’s disease, Parkinson’s disease, diabetes, pain, and cancer. A radiotracer for functional positron emission tomography (PET) imaging could be used to study the kinase in brain disorders and to facilitate the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Chem Neurosci
Prif Awduron: Prabhakaran, Jaya, Zanderigo, Francesca, Solingapuram Sai, Kiran Kumar, Rubin-Falcone, Harry, Jorgensen, Matthew J., Kaplan, Jay R., Mintz, Akiva, Mann, J. John, Dileep Kumar, J. S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559324/
https://ncbi.nlm.nih.gov/pubmed/28485573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00376
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