Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes

Overproduction of extracellular diphosphate due to hydrolysis of ATP by NPP1 leads to pathological calcium diphosphate (pyrophosphate) dihydrate deposition (CPPD) in cartilage, resulting in a degenerative joint disease that today lacks a cure. Here, we targeted the identification of novel NPP1 inhib...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Purinergic Signal
Main Authors: Nassir, Molhm, Arad, Uri, Lee, Sang-Yong, Journo, Shani, Mirza, Salahuddin, Renn, Christian, Zimmermann, Herbert, Pelletier, Julie, Sévigny, Jean, Müller, Christa E., Fischer, Bilha
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2019
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635514/
https://ncbi.nlm.nih.gov/pubmed/31025169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-019-09649-2
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker