Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39

Extracellular ATP mediates proinflammatory and antiproliferative effects via activation of P2 nucleotide receptors. In contrast, its metabolite, the nucleoside adenosine, is strongly immunosuppressive and enhances tumor proliferation and metastasis. The conversion of ATP to adenosine is catalyzed by...

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Detalhes bibliográficos
Publicado no:Mar Drugs
Main Authors: Lopez, Vittoria, Schäkel, Laura, Schuh, H. J. Maximilian, Schmidt, Michael S., Mirza, Salahuddin, Renn, Christian, Pelletier, Julie, Lee, Sang-Yong, Sévigny, Jean, Alban, Susanne, Bendas, Gerd, Müller, Christa E.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7911304/
https://ncbi.nlm.nih.gov/pubmed/33499103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md19020051
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