Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39

Extracellular ATP mediates proinflammatory and antiproliferative effects via activation of P2 nucleotide receptors. In contrast, its metabolite, the nucleoside adenosine, is strongly immunosuppressive and enhances tumor proliferation and metastasis. The conversion of ATP to adenosine is catalyzed by...

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Publicado en:Mar Drugs
Main Authors: Lopez, Vittoria, Schäkel, Laura, Schuh, H. J. Maximilian, Schmidt, Michael S., Mirza, Salahuddin, Renn, Christian, Pelletier, Julie, Lee, Sang-Yong, Sévigny, Jean, Alban, Susanne, Bendas, Gerd, Müller, Christa E.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7911304/
https://ncbi.nlm.nih.gov/pubmed/33499103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md19020051
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