Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapy

Nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) catalyzes the hydrolysis of extracellular nucleotides. It is expressed by immune cells and some carcinomas, e.g. of kidney and colon. Together with ecto-5′-nucleotidase (CD73), NPP3 produces immunosuppressive, cancer-promoting adenosine, and has t...

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Bibliographic Details
Published in:RSC Med Chem
Main Authors: Lee, Sang-Yong, Namasivayam, Vigneshwaran, Boshta, Nader M., Perotti, Arianna, Mirza, Salahuddin, Bua, Silvia, Supuran, Claudiu T., Müller, Christa E.
Format: Artigo
Language:Inglês
Published: RSC 2021
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292979/
https://ncbi.nlm.nih.gov/pubmed/34355184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1md00117e
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