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Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3)

Ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) is a membrane-bound glycoprotein that regulates extracellular levels of nucleotides. NPP3 is known to contribute to the immune response on basophils by hydrolyzing ATP and to regulate the glycosyltransferase activity in Neuro2a cells. Here, w...

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Publicado en:Sci Rep
Autores principales: Döhler, Christoph, Zebisch, Matthias, Sträter, Norbert
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052110/
https://ncbi.nlm.nih.gov/pubmed/30022031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28814-y
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