Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

Nucleotide pyrophosphatase/phosphodiesterase type 1 (NPP1) is a membrane glycoprotein involved in the hydrolysis of extracellular nucleotides. Its major substrate is ATP which is converted to AMP and diphosphate. NPP1 was proposed as a new therapeutic target in brain cancer and immuno-oncology. Seve...

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Publicat a:Front Pharmacol
Autors principals: Lee, Sang-Yong, Sarkar, Soumya, Bhattarai, Sanjay, Namasivayam, Vigneshwaran, De Jonghe, Steven, Stephan, Holger, Herdewijn, Piet, El-Tayeb, Ali, Müller, Christa E.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309242/
https://ncbi.nlm.nih.gov/pubmed/28261095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00054
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