Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes

Overproduction of extracellular diphosphate due to hydrolysis of ATP by NPP1 leads to pathological calcium diphosphate (pyrophosphate) dihydrate deposition (CPPD) in cartilage, resulting in a degenerative joint disease that today lacks a cure. Here, we targeted the identification of novel NPP1 inhib...

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Publicado no:Purinergic Signal
Main Authors: Nassir, Molhm, Arad, Uri, Lee, Sang-Yong, Journo, Shani, Mirza, Salahuddin, Renn, Christian, Zimmermann, Herbert, Pelletier, Julie, Sévigny, Jean, Müller, Christa E., Fischer, Bilha
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635514/
https://ncbi.nlm.nih.gov/pubmed/31025169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-019-09649-2
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