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Phosphatidylinositol 4,5-bisphosphate drives Ca(2+)-independent membrane penetration by the tandem C2 domain proteins synaptotagmin-1 and Doc2β

Exocytosis mediates the release of neurotransmitters and hormones from neurons and neuroendocrine cells. Tandem C2 domain proteins in the synaptotagmin (syt) and double C2 domain (Doc2) families regulate exocytotic membrane fusion via direct interactions with Ca(2+) and phospholipid bilayers. Syt1 i...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bradberry, Mazdak M., Bao, Huan, Lou, Xiaochu, Chapman, Edwin R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635456/
https://ncbi.nlm.nih.gov/pubmed/31147445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007929
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