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Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes
Cytochrome P450 (P450) enzymes are major catalysts involved in the oxidations of most drugs, steroids, carcinogens, fat-soluble vitamins, and natural products. The binding of substrates to some of the 57 human P450s and other mammalian P450s is more complex than a two-state system and has been propo...
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| Gepubliceerd in: | J Biol Chem |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6635447/ https://ncbi.nlm.nih.gov/pubmed/31147443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009305 |
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