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Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug-Metabolizing Enzymes as a Response to Redox Alteration

The lumen of the endoplasmic reticulum (ER) provides an oxidizing environment to aid in the formation of disulfide bonds, which is tightly regulated by both antioxidant proteins and small molecules. On the cytoplasmic side of the ER, cytochrome P450 (P450) proteins have been identified as a superfam...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Albertolle, Matthew E., Phan, Thanh T. N., Pozzi, Ambra, Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930400/
https://ncbi.nlm.nih.gov/pubmed/29374135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000382
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