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Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia

Autophagy is associated with both survival and cell death in myeloid malignancies. Therefore, deciphering its role in different genetically defined subtypes of acute myeloid leukemia (AML) is critical. Activating mutations of the KIT receptor tyrosine kinase are frequently detected in core-binding f...

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Bibliografski detalji
Izdano u:Oncogenesis
Glavni autori: Larrue, Clément, Heydt, Quentin, Saland, Estelle, Boutzen, Héléna, Kaoma, Tony, Sarry, Jean-Emmanuel, Joffre, Carine, Récher, Christian
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635375/
https://ncbi.nlm.nih.gov/pubmed/31311917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-019-0148-9
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