Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia

Acute myeloid leukemia (AML) is characterized by the accumulation of malignant blasts with impaired differentiation programs caused by recurrent mutations, such as the isocitrate dehydrogenase (IDH) mutations found in 15% of AML patients. These mutations result in the production of the oncometabolit...

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Pubblicato in:J Exp Med
Autori principali: Boutzen, Héléna, Saland, Estelle, Larrue, Clément, de Toni, Fabienne, Gales, Lara, Castelli, Florence A., Cathebas, Mathilde, Zaghdoudi, Sonia, Stuani, Lucille, Kaoma, Tony, Riscal, Romain, Yang, Guangli, Hirsch, Pierre, David, Marion, De Mas-Mansat, Véronique, Delabesse, Eric, Vallar, Laurent, Delhommeau, François, Jouanin, Isabelle, Ouerfelli, Ouathek, Le Cam, Laurent, Linares, Laetitia K., Junot, Christophe, Portais, Jean-Charles, Vergez, François, Récher, Christian, Sarry, Jean-Emmanuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2016
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821643/
https://ncbi.nlm.nih.gov/pubmed/26951332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150736
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