Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia

Acute myeloid leukemia (AML) is characterized by the accumulation of malignant blasts with impaired differentiation programs caused by recurrent mutations, such as the isocitrate dehydrogenase (IDH) mutations found in 15% of AML patients. These mutations result in the production of the oncometabolit...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Boutzen, Héléna, Saland, Estelle, Larrue, Clément, de Toni, Fabienne, Gales, Lara, Castelli, Florence A., Cathebas, Mathilde, Zaghdoudi, Sonia, Stuani, Lucille, Kaoma, Tony, Riscal, Romain, Yang, Guangli, Hirsch, Pierre, David, Marion, De Mas-Mansat, Véronique, Delabesse, Eric, Vallar, Laurent, Delhommeau, François, Jouanin, Isabelle, Ouerfelli, Ouathek, Le Cam, Laurent, Linares, Laetitia K., Junot, Christophe, Portais, Jean-Charles, Vergez, François, Récher, Christian, Sarry, Jean-Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821643/
https://ncbi.nlm.nih.gov/pubmed/26951332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150736
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