A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53(wt) osteosarcoma cells

The p53 protein is engaged in the repair of DNA mutations and elimination of heavily damaged cells, providing anti-cancer protection. Dysregulation of p53 activity is a crucial step in carcinogenesis. This dysregulation is often caused by the overexpression of negative regulators of p53, among which...

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Vydáno v:FEBS J
Hlavní autoři: Skalniak, Lukasz, Twarda-Clapa, Aleksandra, Neochoritis, Constantinos G., Surmiak, Ewa, Machula, Monika, Wisniewska, Aneta, Labuzek, Beata, Ali, Ameena M., Krzanik, Sylwia, Dubin, Grzegorz, Groves, Matthew, Dömling, Alexander, Holak, Tad A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6634946/
https://ncbi.nlm.nih.gov/pubmed/30715803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14774
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