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GSK3β Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

Myelin-associated inhibitors (MAIs) contribute to failed regeneration in the CNS. The intracellular signaling pathways through which MAIs block axonal repair remain largely unknown. Here, we report that the kinase GSK3β is directly phosphorylated and inactivated by MAIs, consequently regulating prot...

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Detalles Bibliográficos
Publicado en:J Neurosci
Autores principales: Alabed, Yazan Z., Pool, Madeline, Ong Tone, Stephan, Sutherland, Calum, Fournier, Alyson E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632347/
https://ncbi.nlm.nih.gov/pubmed/20410116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6154-09.2010
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