Acute Polyglutamine Expression in Inducible Mouse Model Unravels Ubiquitin/Proteasome System Impairment and Permanent Recovery Attributable to Aggregate Formation

The presence of intracellular ubiquitylated inclusions in neurodegenerative disorders and the role of the ubiquitin/proteasome system (UPS) in degrading abnormal hazardous proteins have given rise to the hypothesis that UPS-impairment underlies neurodegenerative processes. However, this remains cont...

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Publicado en:J Neurosci
Autores principales: Ortega, Zaira, Díaz-Hernández, Miguel, Maynard, Christa J., Hernández, Félix, Dantuma, Nico P., Lucas, José J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632247/
https://ncbi.nlm.nih.gov/pubmed/20220001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5673-09.2010
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