TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression

BACKGROUND: The major limitation of organ transplantation is the shortage of available organs. Xenotransplantation is considered to be an effective way to resolve the problem. Immune rejection is a major hurdle for the successful survival of pig xenografts in primate recipients. Cytokines play impor...

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Bibliografiske detaljer
Udgivet i:Cell Commun Signal
Main Authors: Gao, Hanchao, Cao, Mengtao, Chen, Pengfei, Cooper, David K. C., Zhao, Yanli, Wei, Ling, Xu, Jia, Cai, Zhiming, Zeng, Changchun, Luan, Shaodong, Mou, Lisha
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6631523/
https://ncbi.nlm.nih.gov/pubmed/31307477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0386-7
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