Celecoxib alleviates pathological cardiac hypertrophy and fibrosis via M1-like macrophage infiltration in neonatal mice

Cardiac hypertrophy is an adaptive response to all forms of heart disease, including hypertension, myocardial infarction, and cardiomyopathy. Cyclooxygenase-2 (COX-2) overexpression results in inflammatory response, cardiac cell apoptosis, and hypertrophy in adult heart after injury. However, immune...

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Published in:iScience
Main Authors: Zhao, Yanli, Zheng, Qi, Gao, Hanchao, Cao, Mengtao, Wang, Huiyun, Chang, Rong, Zeng, Changchun
Format: Artigo
Language:Inglês
Published: Elsevier 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967012/
https://ncbi.nlm.nih.gov/pubmed/33748715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102233
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