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Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk. We address how cytoplasmic and axonemal dynein MTBDs bind mic...

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Publicat a:eLife
Autors principals: Lacey, Samuel E, He, Shaoda, Scheres, Sjors HW, Carter, Andrew P
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629372/
https://ncbi.nlm.nih.gov/pubmed/31264960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47145
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