Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma

Oncolytic viruses induce local tumor destruction and inflammation. Whether virotherapy can also overcome immunosuppression in noninfected tumor areas is under debate. To address this question, we have explored immunologic effects of oncolytic herpes simplex viruses (oHSVs) in a genetically engineere...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Wirsching, Hans-Georg, Zhang, Huajia, Szulzewsky, Frank, Arora, Sonali, Grandi, Paola, Cimino, Patrick J., Amankulor, Nduka, Campbell, Jean S., McFerrin, Lisa, Pattwell, Siobhan S., Ene, Chibawanye, Hicks, Alexandra, Ball, Michael, Yan, James, Zhang, Jenny, Kumasaka, Debrah, Pierce, Robert H., Weller, Michael, Finer, Mitchell, Quéva, Christophe, Glorioso, Joseph C., Houghton, A. McGarry, Holland, Eric C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629248/
https://ncbi.nlm.nih.gov/pubmed/31292299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128217
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