Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma

Oncolytic viruses induce local tumor destruction and inflammation. Whether virotherapy can also overcome immunosuppression in noninfected tumor areas is under debate. To address this question, we have explored immunologic effects of oncolytic herpes simplex viruses (oHSVs) in a genetically engineere...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:JCI Insight
المؤلفون الرئيسيون: Wirsching, Hans-Georg, Zhang, Huajia, Szulzewsky, Frank, Arora, Sonali, Grandi, Paola, Cimino, Patrick J., Amankulor, Nduka, Campbell, Jean S., McFerrin, Lisa, Pattwell, Siobhan S., Ene, Chibawanye, Hicks, Alexandra, Ball, Michael, Yan, James, Zhang, Jenny, Kumasaka, Debrah, Pierce, Robert H., Weller, Michael, Finer, Mitchell, Quéva, Christophe, Glorioso, Joseph C., Houghton, A. McGarry, Holland, Eric C.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2019
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629248/
https://ncbi.nlm.nih.gov/pubmed/31292299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128217
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