Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma

Oncolytic viruses induce local tumor destruction and inflammation. Whether virotherapy can also overcome immunosuppression in noninfected tumor areas is under debate. To address this question, we have explored immunologic effects of oncolytic herpes simplex viruses (oHSVs) in a genetically engineere...

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Pubblicato in:JCI Insight
Autori principali: Wirsching, Hans-Georg, Zhang, Huajia, Szulzewsky, Frank, Arora, Sonali, Grandi, Paola, Cimino, Patrick J., Amankulor, Nduka, Campbell, Jean S., McFerrin, Lisa, Pattwell, Siobhan S., Ene, Chibawanye, Hicks, Alexandra, Ball, Michael, Yan, James, Zhang, Jenny, Kumasaka, Debrah, Pierce, Robert H., Weller, Michael, Finer, Mitchell, Quéva, Christophe, Glorioso, Joseph C., Houghton, A. McGarry, Holland, Eric C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629248/
https://ncbi.nlm.nih.gov/pubmed/31292299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128217
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