Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma

Oncolytic viruses induce local tumor destruction and inflammation. Whether virotherapy can also overcome immunosuppression in noninfected tumor areas is under debate. To address this question, we have explored immunologic effects of oncolytic herpes simplex viruses (oHSVs) in a genetically engineere...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Wirsching, Hans-Georg, Zhang, Huajia, Szulzewsky, Frank, Arora, Sonali, Grandi, Paola, Cimino, Patrick J., Amankulor, Nduka, Campbell, Jean S., McFerrin, Lisa, Pattwell, Siobhan S., Ene, Chibawanye, Hicks, Alexandra, Ball, Michael, Yan, James, Zhang, Jenny, Kumasaka, Debrah, Pierce, Robert H., Weller, Michael, Finer, Mitchell, Quéva, Christophe, Glorioso, Joseph C., Houghton, A. McGarry, Holland, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629248/
https://ncbi.nlm.nih.gov/pubmed/31292299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128217
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