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SCN5A mutation G615E results in Na(V)1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity
SCN5A is expressed in cardiomyocytes and gastrointestinal (GI) smooth muscle cells (SMCs) as the voltage-gated mechanosensitive sodium channel Na(V)1.5. The influx of Na(+) through Na(V)1.5 produces a fast depolarization in membrane potential, indispensable for electrical excitability in cardiomyocy...
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| 出版年: | Channels (Austin) |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6629189/ https://ncbi.nlm.nih.gov/pubmed/31262209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2019.1632670 |
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