SCN5A mutation G615E results in Na(V)1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

SCN5A is expressed in cardiomyocytes and gastrointestinal (GI) smooth muscle cells (SMCs) as the voltage-gated mechanosensitive sodium channel Na(V)1.5. The influx of Na(+) through Na(V)1.5 produces a fast depolarization in membrane potential, indispensable for electrical excitability in cardiomyocy...

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Detalhes bibliográficos
Publicado no:Channels (Austin)
Main Authors: Strege, Peter R., Mercado-Perez, Arnaldo, Mazzone, Amelia, Saito, Yuri A., Bernard, Cheryl E., Farrugia, Gianrico, Beyder, Arthur
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629189/
https://ncbi.nlm.nih.gov/pubmed/31262209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2019.1632670
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